QTC Care 放射科专家
Albert Koong, M.D., Ph.D., FACR, FASTRO
※教育背景
•1996 Northwestern University Medical School, Chicago, IL, USA, MD, Medicine
•1994 Stanford University School of Medicine, Stanford, CA, USA, PHD, Cancer Biology
•1989 Stanford University, Stanford, CA, USA, BS, Biology
※医学认证
•美国放射学委员会放射肿瘤科医学认证(2001年)
※获奖荣誉
• 史蒂夫，乔布斯(Steve Jobs)的主治医师
• 2013入选“康纳利城堡”全美最佳医生排名
※ 专长领域
• 全科肿瘤放射治疗
• 立体定向放射治疗（SBRT）
• 立体定向放射治疗（SABR）
• 高度靶向放射治疗技术在胃肠道恶性肿瘤中的应用
※ 临床研究方向
他的NIH / NCI资助的实验室研究主要研究内质网（ER）应激在肿瘤生长和转移中的作用。他的主要实验室研究重点是开发针对肿瘤微环境调控的信号通路的治疗方法，并开发可预测临床结果的生物标志物。
※ 所属医院
MD安德森癌症中心
图片来源：网络
※ 医院任职
• MD安德森癌症中心放射肿瘤科主任
• MD安德森癌症中心放射肿瘤科教授
※ 学术任职
• 美国放射科学院(FACR)及ASTRO(FASTRO)的研究员
• 美国国家综合癌症网络（NCCN）胰腺癌委员会会员
出版著作
• Yang Z, Chang Y, Brock KK, Cazoulat G, Koay EJ, Koong AC, Herman JM, Park PC, Poenisch F, Li Q, Yang K, Wu G, Anderson B, Ohrt AN, Li Y, Zhu XR, Zhang X, Li H. Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies. Radiother Oncol 134:101-109, 2019. e-Pub 2019. PMID: 31005203.
• Bhutani MS, Cazacu IM, Luzuriaga Chavez AA, Singh BS, Wong FCL, Erwin WD, Tamm EP, Mathew GG, Le DB, Koay EJ, Taniguchi CM, Minsky BD, Pant S, Tzeng CD, Koong AC, Varadhachary GR, Katz MHG, Wolff RA, Fogelman DR, Herman JM. Novel EUS-guided brachytherapy treatment of pancreatic cancer with phosphorus-32 microparticles: first United States experience. VideoGIE 4(5):223-225, 2019. e-Pub 2019. PMID: 31065616.
• Deng W, Xu C, Liu A, van Rossum PSN, Deng W, Liao Z, Koong AC, Mohan R, Lin SH. The relationship of lymphocyte recovery and prognosis of esophageal cancer patients with severe radiation-induced lymphopenia after chemoradiation therapy. Radiother Oncol 133:9-15, 2019. e-Pub 2019. PMID: 30935587.
• Tao R, Ager B, Lloyd S, Torgeson A, Denney M, Gaffney D, Kharofa J, Lin SH, Koong AC, Anzai Y, Hoffman JM. Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy. J Gastrointest Oncol 9(6):1044-1053, 2018. PMID: 30603123.
• Qian Y, Von Eyben R, Liu Y, Chin FT, Miao Z, Apte S, Carter JN, Binkley MS, Pollom EL, Harris JP, Prionas ND, Kissel M, Simmons A, Diehn M, Shultz DB, Brown JM, Maxim PG, Koong AC, Graves EE, Loo BW. 18F-EF5 PET-based Imageable Hypoxia Predicts Local Recurrence in Tumors Treated With Highly Conformal Radiation Therapy. Int J Radiat Oncol Biol Phys 102(4):1183-1192, 2018. e-Pub 2018. PMID: 29859786.
• Elganainy D, Holliday EB, Taniguchi CM, Smith GL, Shroff R, Javle M, Raghav K, Kaseb A, Aloia TA, Vauthey JN, Tzeng CD, Herman JM, Koong AC, Krishnan SX, Minsky BD, Crane CH, Das P, Koay EJ. Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma. Cancer Med 7(10):4880-4892, 2018. e-Pub 2018. PMID: 30152073.
• Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen SC, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A 115(42):10756-10761, 2018. e-Pub 2018. PMID: 30201710.
• Toesca DAS, Koong AJ, von Eyben R, Koong AC, Chang DT. Stereotactic body radiation therapy for adrenal gland metastases: Outcomes and toxicity. Adv Radiat Oncol 3(4):621-629, 2018. e-Pub 2018. PMID: 30370363.
• Colbert LE, Rebueno N, Moningi S, Beddar S, Sawakuchi GO, Herman JM, Koong AC, Das P, Holliday EB, Koay EJ, Taniguchi CM. Dose escalation for locally advanced pancreatic cancer: How high can we go?. Adv Radiat Oncol 3(4):693-700, 2018. e-Pub 2018. PMID: 30370371.
• Fang P, Jiang W, Davuluri R, Xu C, Krishnan S, Mohan R, Koong AC, Hsu CC, Lin SH. High lymphocyte count during neoadjuvant chemoradiotherapy is associated with improved pathologic complete response in esophageal cancer. Radiother Oncol 128(3):584-590, 2018. e-Pub 2018. PMID: 29530432.
• Chiou SH, Dorsch M, Kusch E, Naranjo S, Kozak MM, Koong AC, Winslow MM, Grüner BM. Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. Sci Rep 8(1):14008, 2018. e-Pub 2018. PMID: 30228296.
• Smith GL, Das P, Herman JM, Koay EJ, Koong AC, Grossberg A, Ludmir E. Comparing Ablative Modalities for Hepatocellular Carcinoma: Cautions in Interpreting Big Data. J Clin Oncol 36(24):JCO2018785428, 2018. e-Pub 2018. PMID: 29945520.
• Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG. Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature 558(7711):600-604, 2018. e-Pub 2018. PMID: 29925948.
• Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Mol Cancer Res 16(5):745-753, 2018. e-Pub 2018. PMID: 29440447.
• Toesca DAS, Koong AJ, Poultsides GA, Visser BC, Haraldsdottir S, Koong AC, Chang DT. Management of Borderline Resectable Pancreatic Cancer. Int J Radiat Oncol Biol Phys 100(5):1155-1174, 2018. PMID: 29722658.
• Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. JAMA Oncol 4(3):e173420, 2018. e-Pub 2018. PMID: 29098284.
• Toesca DAS, Ibragimov B, Koong AJ, Xing L, Koong AC, Chang DT. Strategies for prediction and mitigation of radiation-induced liver toxicity. J Radiat Res 59(suppl_1):i40-i49, 2018. e-Pub 2018. PMID: 29432550.
• Prayongrat A, Umegaki K, van der Schaaf A, Koong AC, Lin SH, Whitaker T, McNutt T, Matsufuji N, Graves E, Mizuta M, Ogawa K, Date H, Moriwaki K, Ito YM, Kobashi K, Dekura Y, Shimizu S, Shirato H. Present developments in reaching an international consensus for a model-based approach to particle beam therapy. J Radiat Res 59(suppl_1):i72-i76, 2018. e-Pub 2018. PMID: 29529229.
• Lin SH, Koong AC. Breathing New Life Into Hypoxia-Targeted Therapies for Non-Small Cell Lung Cancer. J Natl Cancer Inst 110(1), 2018. PMID: 28922792.
• Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM. Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival. Br J Cancer 117(12):1874-1882, 2017. e-Pub 2017. PMID: 28982112.
• Chin AL, Pollom EL, Qian Y, Koong AC, Chang DT. Impact of Intensity-Modulated Radiotherapy on Health Care Costs of Patients With Anal Squamous Cell Carcinoma. J Oncol Pract 13(12):JOP2017024810, 2017. e-Pub 2017. PMID: 29035618.
• Kozak MM, von Eyben R, Pai JS, Anderson EM, Welton ML, Shelton AA, Kin C, Koong AC, Chang DT. The Prognostic Significance of Pretreatment Hematologic Parameters in Patients Undergoing Resection for Colorectal Cancer. Am J Clin Oncol 40(4):405-412, 2017. PMID: 25756348.
• Koong AC, Tepper JE. Introduction. Semin Radiat Oncol 27(3):189, 2017. e-Pub 2017. PMID: 28577825.
• Pollom EL, Lee K, Durkee BY, Grade M, Mokhtari DA, Wahl DR, Feng M, Kothary N, Koong AC, Owens DK, Goldhaber-Fiebert J, Chang DT. Cost-effectiveness of Stereotactic Body Radiation Therapy versus Radiofrequency Ablation for Hepatocellular Carcinoma: A Markov Modeling Study. Radiology 283(2):460-468, 2017. e-Pub 2017. PMID: 28045603.
• Pollom EL, Wang G, Harris JP, Koong AC, Bendavid E, Bhattacharya J, Chang DT. The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys 98(1):177-185, 2017. e-Pub 2017. PMID: 28258896.
• Toesca DAS, Osmundson EC, von Eyben R, Shaffer JL, Koong AC, Chang DT. Assessment of hepatic function decline after stereotactic body radiation therapy for primary liver cancer. Pract Radiat Oncol 7(3):173-182, 2017. e-Pub 2016. PMID: 28343896.
• Kino A, Shaffer J, Maturen KE, Schmiedeskamp H, Koong AC, Chang DT, Fleischmann D, Kamaya A. Perfusion CT measurements predict tumor response in rectal carcinoma. Abdom Radiol (NY) 42(4):1132-1140, 2017. PMID: 28008455.
• Jones WE, Suh WW, Abdel-Wahab M, Abrams RA, Azad N, Das P, Dragovic J, Goodman KA, Jabbour SK, Konski AA, Koong AC, Kumar R, Lee P, Pawlik TM, Small W, Herman JM, Expert Panel on Radiation OncologyGastrointestinal. ACR Appropriateness Criteria Resectable Pancreatic Cancer. Am J Clin Oncol 40(2):109-117, 2017. PMID: 28230650.
• Toesca DA, Pollom EL, Poullos PD, Flynt L, Cui Y, Quon A, von Eyben R, Koong AC, Chang DT. Assessing local progression after stereotactic body radiation therapy for unresectable pancreatic adenocarcinoma: CT versus PET. Pract Radiat Oncol 7(2):120-125, 2017. e-Pub 2016. PMID: 28274396.
• Pollom EL, Alagappan M, Park LS, Whittemore AS, Koong AC, Chang DT. Does radiotherapy still have a role in unresected biliary tract cancer?. Cancer Med 6(1):129-141, 2017. e-Pub 2016. PMID: 27891822.
• Toesca DA, Osmundson EC, Eyben RV, Shaffer JL, Lu P, Koong AC, Chang DT. Central liver toxicity after SBRT: An expanded analysis and predictive nomogram. Radiother Oncol 122(1):130-136, 2017. e-Pub 2016. PMID: 27865544.
